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The dose is high because oral bioavailability is low, and there's no penalty for pushing it

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

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Guerra BA, Bolin AP, Morandi AC, Otton R (2012) Glycolaldehyde impairs neutrophil biochemical parameters by an oxidative and calcium-dependent mechanismProtective role of antioxidants astaxanthin and vitamin C

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